Clustered regularly interspaced short palindromic repeats genome editing has already reinvented the direction of genetic and stem cell research. For more complex diseases it allows scientists to simultaneously create multiple genetic changes to a single cell. Technologies for correcting multiple mutations in an in vivo system are already in development. On the surface, the advent and use of gene editing technologies is a powerful tool to reduce human suffering by eradicating complex disease that has a genetic etiology. Gene drives are (...) CRISPR mediated alterations to genes that allow them to be passed on to subsequent populations at rates that approach one hundred per cent transmission. Therefore, from an anticipatory biomedical ethics perspective, it is possible to conceive gene drive being used with CRISPR to permanently ameliorate aberrant genes from wild-type populations containing mutations. However, there are also a number of possible side effects that could develop as the result of combining gene editing and gene drive technologies in an effort to eradicate complex diseases. In this paper, we critically analyse the hypothesis that the combination of CRISPR and gene drive will have a deleterious effect on human populations from an ethical perspective by developing an anticipatory ethical analysis of the implications for the use of CRISPR together with gene drive in humans. (shrink)

Machine learning algorithms pervade contemporary society. They are integral to social institutions, inform processes of governance, and animate the mundane technologies of daily life. Consistently, the outcomes of machine learning reflect, reproduce, and amplify structural inequalities. The field of fair machine learning has emerged in response, developing mathematical techniques that increase fairness based on anti-classification, classification parity, and calibration standards. In practice, these computational correctives invariably fall short, operating from an algorithmic idealism that does not, and cannot, address systemic, Intersectional (...) stratifications. Taking present fair machine learning methods as our point of departure, we suggest instead the notion and practice of algorithmic reparation. Rooted in theories of Intersectionality, reparative algorithms name, unmask, and undo allocative and representational harms as they materialize in sociotechnical form. We propose algorithmic reparation as a foundation for building, evaluating, adjusting, and when necessary, omitting and eradicating machine learning systems. (shrink)

Diese Festschrift für Michael Fischer ist ein Patchwork und eine wunderbare Mischung aus Wissenschaft, Persönlichem, Freundschaft und Genuss. Sie setzt sich aus unterschiedlichen und vielseitigen Texten, Zeichnungen und Bildern zusammen, von Menschen, die ihn begleitet haben, manche viele Jahre, manche nur eine kurze, aber entscheidende Zeit. Studentinnen und Studenten, die von ihm gelernt haben, Kolleginnen und Kollegen, die mit ihm Ideen entwickelt, Projekte initiiert und geforscht haben, Freunden aus Kunst und Kultur, Theater, Oper und den Bühnen des Lebens, nämlich: (...) Eric Hobsbawm, Claudio Magris, André Glucksmann, Wolf Singer, Johannes Hahn, Volker Gerhardt, Thomas Fischer, Rudolf (+) und Gundl Hradil, Helga Rabl-Stadler, Gerard Mortier, Jürgen Flimm, Brita Steinwendtner, Veit Heinichen, Peter Ruzicka, André Tubeuf, Thomas Oberender, Stefan Zweifel, Hermann Lübbe, Eduardo Chitas, Wilhelm Donner, Hans Eichhorn, Reinhard Kacianka, Tina Perisutti, Ulrich H. J. Körtner, Markus Hengstschläger, Henriette und Conrad Ulrich-Hürlimann, Michael Hagner, Thomas Macho, Johann Weyringer, Birgit Recki, Walther Ch. Zimmerli, Andreas Cesana, Kurt Seelmann. (shrink)

The Politics of the Texbook analyzes the factors that shape production, distribution and reception of school texts through original essays which emphasize the double-edged quality of textbooks. Textbooks are viewed as systems of moral regulation in the struggle of powerful groups to build political and cultural accord. They are also regarded as the site of popular resistance around discloding the interest underlying schoolknowledge and incorporating alternative traditions.

Sport builds character. If this is true, why is there a consistent stream of news detailing the bad behavior of athletes? We are bombarded with accounts of elite athletes using banned performance-enhancing substances, putting individual glory ahead of the excellence of the team, engaging in disrespectful and even violent behavior towards opponents, and seeking victory above all else. We are also given a steady diet of more salacious stories that include various embarrassing, immoral, and illegal behaviors in the private lives (...) of elite athletes. Elite sport is not alone in this; youth sport has its own set of moral problems. Parents assault officials, undermine coaches, encourage a win-at-all costs mentality, and in many cases ruin sport for their children. (shrink)

The laboratory animal environment: room for concern.

Proposals for a universal basic income have reemerged in public discourse for a variety of reasons. Marx’s critique of exploitation suggests two apparently opposed positions on a basic income. On the one hand, a basic income funded from taxes on labor would appear to be exploitative of workers. On the other hand, a basic income liberates everyone from the vulnerable condition in which one is forced to sell one’s labor in order to survive, and so seems to be one way (...) of abolishing exploitation at its root. This paper will develop a conception of exploitation that resolves the conflict in favor of basic income. The conception of exploitation is grounded in a liberal egalitarian conception of justice rather than in Marx’s labor theory of value or an exclusive focus on the worker-capitalist relation. This position is not premised on an acceptance of the basic institutions of capitalism, but rather is a standpoint from which to evaluate them. It is not necessary to downsize our ideas of freedom and equality. But it is less obvious than it appeared in classic Marxist formulations that socialism is necessary for social justice. To quote the title of a famous article, there could be a ‘capitalist road to communism’, if a substantial basic income is feasible in a capitalist society. (shrink)

Although much of the focus on responsible conduct in research has been defined by courses or online training, it is generally understood that this is less important than what happens in the research environment. On the assumption that providing faculty with tools and resources to address the ethical dimensions of the practice of research would be useful, a new workshop was convened ten times across seven academic institutions and at the annual meeting of a professional society. Workshops were attended by (...) 91 faculty, 71 of whom completed evaluations strongly supportive of the value of the workshop. Surveys of trainees identified by the faculty allowed for invitations to complete an online survey before and 6 months after the workshops, respectively resulting in response rates of 43 and 51%. Faculty and trainees were highly supportive of the feasibility, relevance, and effectiveness of the implementation by the faculty of one or more of the five strategies featured in the workshop. However, surprisingly over 70% of the trainees reported use of one or more of those strategies prior to faculty participation in the workshops. In sum, the workshops for faculty were successful, and the proposed strategies were deemed of value, but it is likely that the faculty voluntarily choosing to participate in these workshops were perhaps not surprisingly faculty who are already engaging in some of these strategies. This model is likely a useful adjunct to encouraging a culture of ethics, but it is not by itself sufficient to do so. (shrink)

The method of reflective equilibrium (MRE) is a method of justification popularized by John Rawls and further developed by Norman Daniels, Michael DePaul, Folke Tersman, and Catherine Z. Elgin, among others. The basic idea is that epistemic agents have justified beliefs if they have succeeded in forming their beliefs into a harmonious system of beliefs which they reflectively judge to be the most plausible. Despite the common reference to MRE as a method, its mechanisms or rules are typically expressed (...) in a metaphorical or simplified manner and are therefore criticized as too vague. Recent efforts to counter this criticism have been directed towards the attempt to provide formal explications of MRE. This paper aims to supplement these efforts by providing an informal working definition of MRE. This approach challenges the view that MRE can adequately be characterized only in the negative as a set of anti-essentialisms. I argue that epistemic agents follow MRE iff they follow four interconnected rules, which are concerned with a minimalistic form of foundationalism, a minimalistic form of fallibilism, a moderate form of holism, and a minimalistic form of rationality. In the critical spirit of MRE, the corresponding working definition is, of course, provisional and revisable. In general, the aim is to contribute to a reflective equilibrium (RE) concerning MRE. If it is successful, this working definition provides a better grasp of the most basic elements of the method and thereby enhances our understanding of it. (shrink)

The just war tradition is an evolving body of tenets for determining when resorting to war is just and how war may be justly executed. Rethinking the Just War Tradition provides a timely exploration in light of new security threats that have emerged since the end of the Cold War, including ongoing conflicts in the Middle East, threats of terror attacks, and genocidal conflicts within states. The contributors are philosophers, political scientists, a U.S. Army officer, and a senior analyst at (...) the Center for Defense Information. They scrutinize some familiar themes in just war theory from fresh and original angles, and also explore altogether new territory. The diverse topics considered include war and the environment, justice in the ending of war, U.S. military hegemony, a general theory of just armed-conflict principles, supreme emergencies, the distinction between combatants and noncombatants, child soldiers, the moral equality of all soldiers, targeted assassination, preventive war, right authority, and armed humanitarian intervention. Clearly written and free of jargon, this book illustrates how the just war tradition can be rethought and applied today. Contributors include Mark Woods, Eric Patterson, Harry van der Linden, John Lango, Frederik Kaufman, Pauline Kaurin, Reuben Brigety II, Rachel Stohl, Michael Brough, Whitley Kaufman, Jordy Rocheleau, Hartley Spatt, and Robert Hoag. (shrink)

Michael W. Fox, the respected Vice President of the Humane Society of the United States, here looks at the biogenetic controversy and draws some troubling conclusions. Biogenetic research is capable of producing new life forms whose effects may alter the intricate balance of Nature in ways no one can foretell. "Superpigs" that grow larger than any pig before, cows that breed on an accelerated cycle, "new" vegetables, tomatoes that won't freeze - such new life forms can now be patented, (...) making them potential sources of enormous profits for biotech companies. And the record of government, academia, and industry is spotty at best at protecting the earth - yet these same forces are in control of the biogenetic future. Superpigs and Wondercorn is at once an eye-opening survey of a dramatic, sometimes frightening new technology and an impassioned plea to use these new tools in the long-term interests of the global ecosystem. (shrink)

Grounded in the canonical gospels and other New Testament passages, especially Philippians 2:1-11, this study offers an account of humility from a Christian perspective.

I define humility as a virtue that includes both proper self-assessment and a self-lowering other-centeredness. I then argue that humility, so understood, is a virtue in the context of sport, for several reasons. Humility is a component of sportspersonship, deters egoism in sport, fuels athletic aspiration and risk-taking, fosters athletic forms of self-knowledge, decreases the likelihood of an athlete seeking to strongly humiliate her opponents or be weakly humiliated by them, and can motivate an athlete to achieve greater levels of (...) excellence in her sport. In the context of team sports, humility can contribute to an athlete being a better teammate, foster unity amidst diversity within a team, and contribute to the overall moral and athletic excellence of a team. I also argue that an individual who is truly the world's greatest athlete can know and communicate this truth, while remaining humble. (shrink)

Provides a philosophical analysis of the numerous and distinct conceptions of parenthood. This work considers such issues as the nature and justification of parental rights, the sources of parental obligations, the value of autonomy, and the moral obligations and tensions present within interpersonal relationships.

Comparing Mill's "Non-Intervention" and Walzer's "Just and Unjust Wars" links two classic statements on just wars of intervention. Doyle concludes that interventionist arguments should go beyond the three paradigmatic cases Walzer explores in "Just and Unjust Wars.".

This article focuses on the significance of acoustical phenomena in the development of the subjectivity of the infant. An attribute of that development, beginning with the breakdown of psychological symbiosis for the infant, is the loss implicit in the eventual participation of the subject in a symbolic order and the consequent acquisition of language. The essay examines how such loss can contribute to the constitution of the subject and the ego of the subject. Two aspects of language, metaphor and metonymy, (...) are examined in regard to their fundamental relationship to subjectivity. The character Echo, from the myth of Narcissus and Echo, is the namesake for a phase of development, the Echo Phase, which is postulated to begin after the third month of life. During this phase, to some extent the development of the subject depends upon intersubjectivity and concomitant auditory and linguistic phenomena. It is an implicit purpose of this essay to understand the advent of the ego as the expression of a phenomenological structure, dependent upon language and intersubjectivity, that mediates between subject and world. ... By chance Narcissus lost track of his companions, started calling "Is anybody here?" and "Here!" said Echo. He looked around in wonderment, called louder "Come to me!" "Come to me!" came back the answer. He looked behind him, and saw no one coming; "Why do you run from me?" and heard his question Repeated in the woods. "Let us get together!" There was nothing Echo would ever say more gladly, "Let us get together!" And to help her words, Out of the woods she came, with arms all ready To fling around his neck. But he retreated: "Keep your hands off," he cried, "and do not touch me! I would die before I give you a chance at me." "I give you a chance at me," and that was all She ever said thereafter, spurned and hiding, Ashamed, in the leafy forests, in lonely caverns. She frets and pines, becomes all gaunt and haggard, Her body dries and shrivels till voice only And bones remain, and then she is voice only For the bones are turned to stone. She hides in woods And no one sees her now along the mountains, But all may hear her, for her voice is living. Ovid, Metamorphoses. (shrink)

The international research on teams, which is inspired by the input-process-output model, is mostly empirical. Researchers in this field look for causal explanations between independent (e.g., team size and team composition) and dependent (e.g., team performance) variables. Recently, some critics have pointed to the deficits in this model. Especially, the temporal, contextual, and dynamic aspects of teams need to be investigated further (multilevel approach). Emergent states, such as team cognitions, team emotions, and team hierarchies, comprise a promising field of study (...) that leads to a more comprehensive and holistic understanding of teams. These emergent states offer an opportunity to reconcile former concepts (Lewin’s gestalt, Koestler’s holarchy, and Cattell’s syntality) with topical team research. Therefore, the future of research on teams may partly lie in its past. (shrink)

Globalisation impacts every aspect of modern society and today's law graduates are expected to deal with complex legal problems that require knowledge and training that goes beyond domestic law. This textbook provides an overview of how law is becoming increasingly transnational, facilitating theoretical and practical engagement with transnational legal institutions and phenomena. It advances an analytic framework that will help students to understand what to look for when they encounter transnational legal institutions and practices, and what are the practical and (...) normative implications of their findings. By considering both the theory and practice of transnational law and taking a discursive approach to the material, students are encouraged to arrive at their own conclusions. Adopting interdisciplinary techniques and using case studies from around the world, this book offers a holistic, balanced exploration of a new and emerging discipline. This title is also available as Open Access on Cambridge Core. (shrink)